Quantitative genetic analysis
Rapid Critical Appraisal (RCA) Comparisons: Quantitative
Name Deneshia Dawkins
QUANTITATIVE
APA Reference
Contreras, J., Hare, E., Chavarria, G., Raventos, H. (2017) Quantitative genetic analysis of anxiety trait in bipolar disorder.
Johnson, C., Follmer, R., Oguz, I., Warren, L., Christensen, G., Fiedorowicz, J., Magnotta, V., Wemmie, J. (2015) Brain abnormalities in bipolar disorder detected by quantitative T1p mapping. Macmillan Publishers Limited.
Purpose and or problem
Does genetics and biopsychosocial problems cause patients with Bipolar disorder to display anxiety?
Does abnormal metabolism in the brain in Bipolar patients limited to one particular area?
Relevance to Nursing
It is important for nurses to learn what triggers anxiety in patients, in order to assess and implement interventions.
This is important for nurses to understand the disease process that will facilitate teaching to patient and family members.
Setting
Other
Country: Central Valley of Costa Rico
Choose an item.
Country: Iowa
Sample
Size : 619
Type: 61 extended families and 51 unrelated healthy controls.
Randomized? Yes ☐ No ☒
Size : 30
Type: 15 with DSM-IV diagnosis of bipolar 1 and 25 normal controlled group with no known psychiatric history
Randomized? Yes ☐ No ☒
Hypothesis
Easy to find? Yes ☒ No ☐
What is it? Subclinical anxiety as a heritable trait genetically correlates wit.h Bipolar Disorder 1
Easy to find? Yes ☒ No ☐
What is it? T1p would be elevated in bipolar 1 disorder.
Independent variable (s)
Anxiety traits
T1 mapping
Dependent variable
Measurement of anxiety experienced over a lifetime
Brain Abnormalities
How is dependent variable measured? (Tools and/or Validity)
By using clinical information obtained from the Dagnostic interview for genetic Studies and using the STAI. The STAI is a self-rated instrument that measures anxiety
Variable measured using a 3 T siemens Tim Trio MRI system
Reliability statistics
Yes ☐ No ☐
If yes, which ones were reported? Click or tap here to enter text.
Yes ☒ No ☐
If yes, which ones were reported? Images were reported showing different sides of the brain.
Data analysis
Quantitative (Choose from drop down).
Descriptive: Choose an item.
Variate: Choose an item.
Correlational: Choose an item.
Inferential: Choose an item.
Other: experimental
Quantitative (Choose from drop down).
Descriptive: Choose an item.
Variate: Choose an item.
Correlational: Choose an item.
Inferential: Choose an item.
Other: experimental
Unusual events?
Yes ☐ No ☒
If yes, explain: Click or tap here to enter text.
Yes ☐ No ☒
If yes, explain: Click or tap here to enter text.
Sample attrition?
Yes ☐ No ☒
If yes, explain: Click or tap here to enter text.
Yes ☐ No ☒
If yes, explain: Click or tap here to enter text.
Findings (Results)
The research was a limited success. The researcher was unable to find significant difference in score of BP1 mood status.
Lithium having a normalized effect on the brain that helps to control BP.
Important to you in your practice?
Yes ☒ No ☐
Explain: The research is important aid in the understanding of BD and why patients with bipolar, react the way they do.
Yes ☒ No ☐
Explain: It helps nurses to understand how someone with bipolar brain works, leading to new evidence based practices.
